HostSeq: a Canadian whole genome sequencing and clinical data resource.

HostSeq was launched in April 2020 as a national initiative to integrate whole genome sequencing data from 10,000 Canadians infected with SARS-CoV-2 with clinical information related to their disease experience. The mandate of HostSeq is to support the Canadian and international research communities in their efforts to understand the risk factors for disease and associated health outcomes and support the development of interventions such as vaccines and therapeutics. HostSeq is a collaboration among 13 independent epidemiological studies of SARS-CoV-2 across five provinces in Canada. Aggregated data collected by HostSeq are made available to the public through two data portals: a phenotype portal showing summaries of major variables and their distributions, and a variant search portal enabling queries in a genomic region. Individual-level data is available to the global research community for health research through a Data Access Agreement and Data Access Compliance Office approval. Here we provide an overview of the collective project design along with summary level information for HostSeq. We highlight several statistical considerations for researchers using the HostSeq platform regarding data aggregation, sampling mechanism, covariate adjustment, and X chromosome analysis. In addition to serving as a rich data source, the diversity of study designs, sample sizes, and research objectives among the participating studies provides unique opportunities for the research community.

A Reflection on the Nexus between South African Land Reform Struggles and the Unresolved National Question

The post-apartheid South African government continues to struggle with its transformation posture, including the quest to redress the racially based land inequalities that have plagued the country since its colonial past. The Covid-19 pandemic, the 2015 #RhodesMustFall and #FeesMustFall movements, and the July 2021 #FreeZuma violence have highlighted both the fragility and the resilience of South African political institutions. Since the formation of the Economic Freedom Fighters (EFF), a left-leaning and militant political party, in 2013, the South African land question has become more vociferously contested within government purview and in the public domain. Unresolved land issues have exposed the failure of the state to resolve one of its most sensitive national questions. We interrogate the land conflict and locate it within the broader national questions that have continued to haunt post-apartheid South Africa. Indeed, the South African land question must be understood holistically, and not solely as an agrarian question. Although the ANC-led government has implemented a land reform scheme under four pillars—land restitution, land redistribution, tenure security, and land development—there are still compelling cases of land hunger and conflict, as well as widespread confusion about the proposed land expropriation without compensation. Despite the rhetoric by government officials, we hold that the land debacle is a manifestation of a failing national question, state fragility, and an incomplete decolonisation process wherein the so-called "political power" held by the majority has not transformed into economic power and the effective redistribution of land to meet the targets of successive administrations. [ABSTRACT FROM AUTHOR] Copyright of International Journal of African Renaissance Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A Reflection on the Nexus between South African Land Reform Struggles and the Unresolved National Question

The post-apartheid South African government continues to struggle with its transformation posture, including the quest to redress the racially based land inequalities that have plagued the country since its colonial past. The Covid-19 pandemic, the 2015 #RhodesMustFall and #FeesMustFall movements, and the July 2021 #FreeZuma violence have highlighted both the fragility and the resilience of South African political institutions. Since the formation of the Economic Freedom Fighters (EFF), a left-leaning and militant political party, in 2013, the South African land question has become more vociferously contested within government purview and in the public domain. Unresolved land issues have exposed the failure of the state to resolve one of its most sensitive national questions. We interrogate the land conflict and locate it within the broader national questions that have continued to haunt post-apartheid South Africa. Indeed, the South African land question must be understood holistically, and not solely as an agrarian question. Although the ANC-led government has implemented a land reform scheme under four pillars—land restitution, land redistribution, tenure security, and land development—there are still compelling cases of land hunger and conflict, as well as widespread confusion about the proposed land expropriation without compensation. Despite the rhetoric by government officials, we hold that the land debacle is a manifestation of a failing national question, state fragility, and an incomplete decolonisation process wherein the so-called “political power” held by the majority has not transformed into economic power and the effective redistribution of land to meet the targets of successive administrations. [ FROM AUTHOR] Copyright of International Journal of African Renaissance Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

COVID-19 AND SOUTH AFRICA–CHINA ASYMMETRIC RELATIONS

While South Africa?China relations were only formalized in 1998, relations between these states date back to the 1800s. South Africa's quest for sustainable development through partnerships with global powers motivated its close ties with China. The 2015 Cape Town Declaration committed the two countries to improve health facilities and disease control. The coronavirus (COVID-19) pandemic presents an opportunity to rethink this partnership. Drawing on desktop research, this article engages the reality of COVID-19 and explores South Africa?China relations in the context of the pandemic. The emergence of the virus in China, its rapid spread, and the high fatality rate have had devastating repercussions across the world. This article argues that Beijing's response to COVID-19 raises more questions than it answers. The outbreak of the virus in China, its response, and emerging cases of racism and xenophobia against Africans in China also raise concerns about the future of South Africa?China relations.

Clinical Profile and Outcome of COVID-19 Cases Admitted at a Tertiary Health Facility In South-West Nigeria

BACKGROUND: Coronavirus Disease 2019 (COVID-19) is anemerging disease with a global spread that has affected millions of lives. In Nigeria, the third wave of the outbreak is being experienced with many patients requiring hospitalization. Being a novel disease, we characterized the clinical profile and outcomes of patients admitted into our isolation centre. METHODS: A case series of 65 COVID-19 patients admitted at theIsolation Centre of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, from June 2020 to March 2021 is presented. Information on demographic characteristics, medical history, symptoms, treatment and outcomes was obtained. Data were analysed using SPSS version 25. RESULTS: Most (47;72.3%) patients were less than 65 years old and 39 (60.0%) were males. The commonest symptoms were cough (42;64.6%), breathlessness (41;63.1%), fever (40;61.5%), muscle aches (40;61.5%), and anosmia (16;24.6%). Hypertension (41;63.1%) and diabetes (18;27.7%) were the most predominant comorbidities. Forty-three patients (66.2%) had supplemental oxygen therapy. The majority (44;70%) of patients were admitted for 10 days or less and 58 (89.3%) patients were discharged home. However, 6 deaths (9.2%) were recorded among patients with advanced comorbidities and severe sepsis with all deaths occuring within 5 days of admission. CONCLUSION: There was a male predominance among patients admitted at the Isolation Centre and all mortalities occurred within five days of admission. Early detection, prompt management of cases with hypoxaemia and optimal treatment of comorbidities are recommended for good outcomes in COVID-19 patients.

Update on regional stroke activation trends during COVID-19 mitigation

Background: The University of Cincinnati Stroke Team provides acute stroke care to the southwest Ohio, northern Kentucky, and southeast Indiana catchment area of ∼2 million people and 30 healthcare facilities. We previously published a significant decline in stroke activations and reperfusion treatment (IV thrombolysis and EVT) rates following state announcements of COVID-19 mitigation measures. Here, we update these trends after state reopening guidelines. Methods: We compared Stroke Team activations and reperfusion treatments logged in a prospectively collected database, comparing the same period in 2020 versus 2019. Kentucky and Ohio announced school and restaurant closures on March 12 and 13, respectively, followed by Indiana. A stepwise reopening of our tristate area started on May 1, 2020. We also compared trends in activations and treatment rates before (Weeks 1-10), during (Weeks 11-17), and after (Weeks 18- 26) the lifting of COVID-19 mitigation efforts using the Poisson test, and graphically with segmented regression analysis. Results: Compared to 2019, stroke team activations declined by 12% in 2020 (95% CI 7 - 16%;p<0.01). During 2020, an initial decline in stroke activations following COVID-19 mitigation announcements was followed by a 28% increase in activations after reopening (Weeks 18-26: 95% CI 15 - 42%;p<0.01). In contrast, compared to 2019, treatment rates were unchanged (0%, 95% CI -15 - 18%;p=1.00), including specifically IV thrombolysis and thrombectomy rates. Similarly, an initial decline in reperfusion treatments was followed by a 24% nonsignificant increase after reopening (95% CI -10 - 71%;p=0.19) in 2020. Conclusion: The initial decline in stroke team activations during COVID-19 mitigation efforts was followed by an increase in activations after reopening. Hospital capacity and 911 services remained fully intact, suggesting that the reduction in activations were related to reduced presentation by patients for emergent stroke care.(Figure Presented).